What is 5-Amino-1MQ?

Overview

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) — an enzyme that sinks methyl groups and NAD+ precursors in adipose tissue. When NNMT is overexpressed, cells burn through NAD+ producing methylnicotinamide instead of fueling sirtuins and mitochondrial repair. The rationale behind the class: inhibiting NNMT in fat tissue preserves NAD+ and methyl donors, shifting the cell back toward oxidative metabolism. Rodent models show measurable fat-mass loss without food restriction. IF the research question is metabolic inefficiency driven by overexpressed NNMT, THEN 5-Amino-1MQ is the tool compound with the cleanest pharmacology. SO it belongs in any protocol probing adipose metabolism, NAD+ homeostasis, or obesity-linked inflammation. ≥99% HPLC purity. CoA with every batch.

Research areas

• NNMT inhibition

  <p>Selective small-molecule inhibitor of nicotinamide N-methyltransferase. Blocks the methyl-sink pathway in adipocytes, sparing NAD+ and S-adenosylmethionine.</p>

• Adipose metabolism

  <p>Published diet-induced obesity models report fat-mass reduction and improved insulin sensitivity without caloric restriction when NNMT is pharmacologically blocked.</p>

• NAD+ sparing

  <p>NNMT consumes nicotinamide (an NAD+ precursor) to make methylnicotinamide. Inhibition restores NAD+ pools, supporting sirtuin activity and mitochondrial output.</p>

• Delivery

  <p>Small molecule, orally bioavailable in rodent models. Reconstitutes in bacteriostatic water for injection protocols. Store lyophilized at 2–8°C.</p>

Storage & handling

Lyophilized 5-Amino-1MQis stored at –20 °C protected from light. Once reconstituted with bacteriostatic water, store at 2–8 °C and use within 30 days for maximum stability.

Frequently asked questions

What is 5-Amino-1MQ?

5-Amino-1MQ (5-Amino-1MQ) is a research compound studied in the area of metabolic. A selective NNMT inhibitor. Studied for its effect on adipose-tissue NAD+ sparing, metabolic efficiency, and fat-mass reduction without caloric restriction.

What is the CAS number of 5-Amino-1MQ?

The CAS registry number of 5-Amino-1MQ is 42464-96-0.

How should 5-Amino-1MQ be stored?

Lyophilized 5-Amino-1MQ should be stored at –20 °C protected from light. Once reconstituted with bacteriostatic water, store at 2–8 °C and use within 30 days for maximum stability.

How is the purity of 5-Amino-1MQ verified?

Every Woosh Labs batch of 5-Amino-1MQ is independently tested by third-party HPLC and mass spectrometry, with a batch-specific Certificate of Analysis published verifying ≥99% purity.

Is 5-Amino-1MQ for human use?

No. 5-Amino-1MQ sold by Woosh Labs is strictly for in-vitro laboratory research by qualified professionals. It is not for human or veterinary use of any kind.