What is Epithalon?

Overview

Epithalon (Ala-Glu-Asp-Gly) is the short-peptide fragment of Epithalamin isolated from the pineal gland by the Russian gerontology group led by Khavinson. Decades of their longitudinal data suggest it upregulates telomerase and shifts aging-related biomarkers toward younger profiles. Why it keeps returning in longevity research: Epithalon is one of the only compounds shown to directly upregulate telomerase activity in somatic cells outside the germline. That mechanism alone is rare — most anti-aging compounds act downstream of the DNA-damage response, not upstream at the replicative-limit level. IF the research hypothesis involves replicative senescence or telomere attrition, THEN Epithalon is the tool peptide with the longest clinical-observation record. SO it belongs in protocols studying aging biomarkers, pineal function, or sleep-wake regulation in older cohorts. Batch-verified, ≥99% HPLC.

Research areas

• Telomerase activation

  <p>Published in-vitro studies show increased telomerase activity in human somatic cells exposed to Epithalon, with corresponding extension of replicative lifespan.</p>

• Pineal & sleep

  <p>Normalizes melatonin rhythm in animal models of pineal insufficiency. Used in sleep-regulation studies in aging cohorts.</p>

• Longitudinal outcomes

  <p>Khavinson&#8217;s multi-decade human cohort data reports reduced all-cause mortality and improved immune markers in older subjects — one of the few peptides with this class of longitudinal evidence.</p>

• Administration

  <p>Subcutaneous or intranasal administration per published protocols. Short plasma half-life is offset by prolonged downstream telomerase signaling.</p>

Storage & handling

Lyophilized Epithalonis stored at –20 °C protected from light. Once reconstituted with bacteriostatic water, store at 2–8 °C and use within 30 days for maximum stability.

Frequently asked questions

What is Epithalon?

Epithalon (Epithalon) is a research compound studied in the area of longevity & anti-aging. A tetrapeptide fragment of Epithalamin. Studied for telomerase upregulation and pineal-gland regulation in longevity research.

What is the CAS number of Epithalon?

The CAS registry number of Epithalon is 307297-39-8.

How should Epithalon be stored?

Lyophilized Epithalon should be stored at –20 °C protected from light. Once reconstituted with bacteriostatic water, store at 2–8 °C and use within 30 days for maximum stability.

How is the purity of Epithalon verified?

Every Woosh Labs batch of Epithalon is independently tested by third-party HPLC and mass spectrometry, with a batch-specific Certificate of Analysis published verifying ≥99% purity.

Is Epithalon for human use?

No. Epithalon sold by Woosh Labs is strictly for in-vitro laboratory research by qualified professionals. It is not for human or veterinary use of any kind.