What is Kisspeptin?

Overview

Kisspeptin-10 (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2) is the 10-amino-acid C-terminal fragment of kisspeptin, the product of the KISS1 gene. It is the shortest form that keeps full activity at the KISS1 receptor (GPR54). Why it matters: kisspeptin signalling sits upstream of GnRH. Activating KISS1R on hypothalamic GnRH neurons triggers GnRH release and, downstream, LH and FSH. That makes Kisspeptin-10 a reference compound for studying how the reproductive axis is switched on. IF the research question is gonadotropin release, puberty timing or reproductive-axis signalling, THEN Kisspeptin-10 is the minimal active ligand to work with. SO it belongs in neuroendocrine and reproductive-physiology research. ≥99% HPLC purity.

Research areas

• KISS1R agonism

  <p>Binds the KISS1 receptor (GPR54) with nanomolar potency. The 10-residue C-terminus is the minimal sequence that keeps full receptor activity.</p>

• GnRH release

  <p>Activates GnRH neurons in the hypothalamus, driving LH and FSH secretion in rodent, primate and human physiology studies.</p>

• Puberty & fertility research

  <p>Loss-of-function KISS1R mutations cause hypogonadotropic hypogonadism, which made kisspeptin a reference compound for studying puberty onset and fertility signalling.</p>

• Study design

  <p>Kisspeptin-10 is cleared quickly from plasma, so studies typically use bolus or infusion designs and measure the gonadotropin response over minutes to hours.</p>

Storage & handling

Lyophilized Kisspeptinis stored at –20 °C protected from light. Once reconstituted with bacteriostatic water, store at 2–8 °C and use within 30 days for maximum stability.

Frequently asked questions

What is Kisspeptin?

Kisspeptin (Kisspeptin-10) is a research compound studied in the area of cognitive. The 10-amino-acid active fragment of kisspeptin. Studied as a KISS1R (GPR54) agonist that sits upstream of GnRH, LH and FSH release.

What is the CAS number of Kisspeptin?

The CAS registry number of Kisspeptin is 374675-21-5.

How should Kisspeptin be stored?

Lyophilized Kisspeptin should be stored at –20 °C protected from light. Once reconstituted with bacteriostatic water, store at 2–8 °C and use within 30 days for maximum stability.

How is the purity of Kisspeptin verified?

Every Woosh Labs batch of Kisspeptin is independently tested by third-party HPLC and mass spectrometry, with a batch-specific Certificate of Analysis published verifying ≥99% purity.

Is Kisspeptin for human use?

No. Kisspeptin sold by Woosh Labs is strictly for in-vitro laboratory research by qualified professionals. It is not for human or veterinary use of any kind.