What is KPV?

Overview

KPV (Lys-Pro-Val) is the three-amino-acid C-terminal fragment of α-melanocyte-stimulating hormone. The pigmentation actions of α-MSH live in its N-terminal sequence, but the anti-inflammatory actions are localized to this short C-terminal tripeptide — separable by the tissue or receptor system being studied. Why this separation matters: KPV inhibits NF-κB translocation and silences downstream TNF-α, IL-1β, and IL-6 transcription across multiple cell types — gut, skin, immune — without triggering melanocortin-receptor-mediated pigmentation. It’s the anti-inflammatory fraction of α-MSH in isolation. IF the research question is compound anti-inflammatory signaling without pigmentation confounders, THEN KPV is the α-MSH fragment with the cleanest pharmacology. SO it belongs in IBD, colitis, wound-healing, and systemic-inflammation research. ≥99% HPLC purity.

Research areas

• NF-κB inhibition

  <p>Blocks nuclear translocation of the p65 subunit. Downregulates TNF-α, IL-1β, IL-6, and IL-8 transcription in macrophages, fibroblasts, and keratinocytes.</p>

• Gut inflammation research

  <p>Studied in DSS-colitis and TNBS-colitis models with measurable reductions in mucosal damage, neutrophil infiltration, and inflammatory cytokine levels.</p>

• Skin & wound repair

  <p>Topical application in dermatitis and wound-healing models shows reduced chronic inflammation and improved re-epithelialization without pigmentation changes.</p>

• Delivery

  <p>Oral, topical, and subcutaneous routes all have published precedent. Small peptide, relatively stable under gastric conditions.</p>

Storage & handling

Lyophilized KPVis stored at –20 °C protected from light. Once reconstituted with bacteriostatic water, store at 2–8 °C and use within 30 days for maximum stability.

Frequently asked questions

What is KPV?

KPV (KPV) is a research compound studied in the area of healing & regeneration. The C-terminal tripeptide of α-MSH. Studied for NF-κB-silencing anti-inflammatory activity in gut, skin, and systemic inflammation models.

What is the CAS number of KPV?

The CAS registry number of KPV is 67727-97-3.

How should KPV be stored?

Lyophilized KPV should be stored at –20 °C protected from light. Once reconstituted with bacteriostatic water, store at 2–8 °C and use within 30 days for maximum stability.

How is the purity of KPV verified?

Every Woosh Labs batch of KPV is independently tested by third-party HPLC and mass spectrometry, with a batch-specific Certificate of Analysis published verifying ≥99% purity.

Is KPV for human use?

No. KPV sold by Woosh Labs is strictly for in-vitro laboratory research by qualified professionals. It is not for human or veterinary use of any kind.