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Research Library · Metabolic

What is Mots-c?

Mots-c (MOTS-c) is a research compound studied in metabolic. A mitochondrial-derived peptide encoded in the 12S rRNA. Studied for AMPK activation, insulin sensitivity, and exercise-mimetic metabolic effects.

Overview

MOTS-c is one of the first recognized mitochondrial-derived peptides — a 16-amino-acid signaling peptide encoded in the mitochondrial 12S rRNA gene. Unlike nuclear-genome-encoded peptides, MOTS-c originates inside the mitochondrion itself, acting as a retrograde signal from mitochondria to nucleus. Why mitochondrial-origin matters: MOTS-c activates AMPK, upregulates PGC-1α, and enhances insulin sensitivity through pathways that parallel the cellular response to exercise. It’s been called an exercise mimetic in the metabolic-research literature. IF the research endpoint is mitochondrial function, insulin sensitivity, or exercise-pathway pharmacology, THEN MOTS-c is the mitochondrial peptide with the densest published evidence. SO it belongs in studies of metabolic aging, type-2 diabetes models, or compound exercise-mimetic signaling. Lyophilized, ≥99% purity, CoA-verified.

Research areas

  • AMPK activation

    <p>Stimulates AMP-activated protein kinase in skeletal muscle and liver. Downstream effects include increased glucose uptake and fatty-acid oxidation.</p>

  • Insulin sensitivity

    <p>Rodent diet-induced obesity models show restored insulin sensitivity and reduced adiposity with chronic MOTS-c administration.</p>

  • Age-related decline

    <p>Circulating MOTS-c falls with age in human cohorts. Supplementation studies in aged mice show partial restoration of metabolic flexibility and exercise capacity.</p>

  • Administration

    <p>Subcutaneous or intraperitoneal in rodent research. Reconstitute with bacteriostatic water; refrigerate reconstituted solution.</p>

Published research

Storage & handling

Lyophilized Mots-cis stored at –20 °C protected from light. Once reconstituted with bacteriostatic water, store at 2–8 °C and use within 30 days for maximum stability.

Frequently asked questions

What is Mots-c?
Mots-c (MOTS-c) is a research compound studied in the area of metabolic. A mitochondrial-derived peptide encoded in the 12S rRNA. Studied for AMPK activation, insulin sensitivity, and exercise-mimetic metabolic effects.
What is the CAS number of Mots-c?
The CAS registry number of Mots-c is 1627580-64-6.
How should Mots-c be stored?
Lyophilized Mots-c should be stored at –20 °C protected from light. Once reconstituted with bacteriostatic water, store at 2–8 °C and use within 30 days for maximum stability.
How is the purity of Mots-c verified?
Every Woosh Labs batch of Mots-c is independently tested by third-party HPLC and mass spectrometry, with a batch-specific Certificate of Analysis published verifying ≥99% purity.
Is Mots-c for human use?
No. Mots-c sold by Woosh Labs is strictly for in-vitro laboratory research by qualified professionals. It is not for human or veterinary use of any kind.

This page is for informational purposes for qualified researchers. All Woosh Labs products are for laboratory research use only and are not intended for human or veterinary use. Nothing here is medical advice or a claim of therapeutic effect.