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Research Library · Cognitive

What is PT-141?

PT-141 (PT-141) is a research compound studied in cognitive. Bremelanotide — a selective MC4R agonist. Studied for centrally-mediated sexual-arousal pharmacology distinct from vascular mechanisms.

Overview

PT-141 (bremelanotide) is the MC4R-selective fragment derived from Melanotan-II. It’s the only FDA-approved libido-targeted pharmaceutical that acts on the central nervous system — specifically on hypothalamic melanocortin-4 receptors — rather than on vascular smooth muscle like the PDE5-inhibitor class. Why the mechanism matters: PDE5 inhibitors (sildenafil, tadalafil) enable erection mechanically by relaxing corpus cavernosum smooth muscle. PT-141 acts upstream on the desire/arousal signal itself. Researchers studying HSDD (hypoactive sexual desire disorder) need a tool that isolates the central mechanism. IF the research question involves central-nervous-system sexual-arousal signaling, THEN PT-141 is the tool with the cleanest published MC4R pharmacology. SO it fits in studies of HSDD, central libido pathways, or MC4R physiology. Batch-verified ≥99% HPLC.

Research areas

  • MC4R activation

    <p>Selective MC4R agonist. Activation of hypothalamic MC4Rs triggers pro-arousal signaling distinct from peripheral vasoactive pathways.</p>

  • HSDD research

    <p>FDA-approved as Vyleesi for premenopausal HSDD. Published trials show improved sexual-desire scores and arousal events in target cohorts.</p>

  • Male & female endpoints

    <p>Unlike PDE5 inhibitors, PT-141 is effective in both sexes because the central mechanism is conserved. Published literature covers both male and female cohorts.</p>

  • Administration

    <p>Subcutaneous, on-demand. Plasma half-life ~2 hours. Dose-dependent nausea is the most common transient effect.</p>

Published research

Storage & handling

Lyophilized PT-141is stored at –20 °C protected from light. Once reconstituted with bacteriostatic water, store at 2–8 °C and use within 30 days for maximum stability.

Frequently asked questions

What is PT-141?
PT-141 (PT-141) is a research compound studied in the area of cognitive. Bremelanotide — a selective MC4R agonist. Studied for centrally-mediated sexual-arousal pharmacology distinct from vascular mechanisms.
What is the CAS number of PT-141?
The CAS registry number of PT-141 is 189691-06-3.
How should PT-141 be stored?
Lyophilized PT-141 should be stored at –20 °C protected from light. Once reconstituted with bacteriostatic water, store at 2–8 °C and use within 30 days for maximum stability.
How is the purity of PT-141 verified?
Every Woosh Labs batch of PT-141 is independently tested by third-party HPLC and mass spectrometry, with a batch-specific Certificate of Analysis published verifying ≥99% purity.
Is PT-141 for human use?
No. PT-141 sold by Woosh Labs is strictly for in-vitro laboratory research by qualified professionals. It is not for human or veterinary use of any kind.

This page is for informational purposes for qualified researchers. All Woosh Labs products are for laboratory research use only and are not intended for human or veterinary use. Nothing here is medical advice or a claim of therapeutic effect.