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Research Library · Healing & regeneration

What is TB-500?

TB-500 (TB-500) is a research compound studied in healing & regeneration. A Thymosin-β4 fragment driving systemic actin-monomer turnover. Studied for tissue migration, angiogenesis, and systemic repair signaling.

Overview

TB-500 is the synthetic fragment of Thymosin-β4, a 43-amino-acid actin-binding protein that governs the free G-actin pool inside cells. By sequestering actin monomers, Thymosin-β4 controls how quickly cells can assemble the cytoskeletal scaffolding they need to migrate into damaged tissue. Why it complements local-acting peptides: BPC-157 is a localized healing signal. TB-500 is systemic — it supports cell migration, angiogenesis, and wound-healing coordination at the whole-organism level. The two are frequently studied as a complementary stack. IF the research question involves systemic cell migration, post-injury cytoskeletal remodeling, or angiogenesis coordination, THEN TB-500 is the Thymosin-β4 fragment with the densest preclinical literature. SO it belongs in tissue-recovery protocols alongside localized repair peptides. Independently verified, ≥99% purity.

Research areas

  • Actin sequestration

    <p>Binds G-actin monomers and regulates their availability for F-actin assembly. Increases cytoskeletal plasticity during cell migration and wound closure.</p>

  • Angiogenesis

    <p>Published cardiac-injury and ischemic-limb models show improved revascularization and capillary density with systemic TB-500 administration.</p>

  • Wound & tendon research

    <p>Accelerated closure rates in dermal wounds; improved biomechanical recovery in rodent tendon-transection models. Effect is additive with BPC-157.</p>

  • Administration

    <p>Subcutaneous or intramuscular; systemic distribution is characteristic. Typical research protocols: 2–5 mg weekly for 4–6 weeks.</p>

Published research

Storage & handling

Lyophilized TB-500is stored at –20 °C protected from light. Once reconstituted with bacteriostatic water, store at 2–8 °C and use within 30 days for maximum stability.

Frequently asked questions

What is TB-500?
TB-500 (TB-500) is a research compound studied in the area of healing & regeneration. A Thymosin-β4 fragment driving systemic actin-monomer turnover. Studied for tissue migration, angiogenesis, and systemic repair signaling.
What is the CAS number of TB-500?
The CAS registry number of TB-500 is 77591-33-4.
How should TB-500 be stored?
Lyophilized TB-500 should be stored at –20 °C protected from light. Once reconstituted with bacteriostatic water, store at 2–8 °C and use within 30 days for maximum stability.
How is the purity of TB-500 verified?
Every Woosh Labs batch of TB-500 is independently tested by third-party HPLC and mass spectrometry, with a batch-specific Certificate of Analysis published verifying ≥99% purity.
Is TB-500 for human use?
No. TB-500 sold by Woosh Labs is strictly for in-vitro laboratory research by qualified professionals. It is not for human or veterinary use of any kind.

This page is for informational purposes for qualified researchers. All Woosh Labs products are for laboratory research use only and are not intended for human or veterinary use. Nothing here is medical advice or a claim of therapeutic effect.