Mots-c

10 × 10mg

A mitochondrial-derived peptide encoded in the 12S rRNA. Studied for AMPK activation, insulin sensitivity, and exercise-mimetic metabolic effects.

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Buy a single vial Research guide

About Mots-c

MOTS-c is one of the first recognized mitochondrial-derived peptides — a 16-amino-acid signaling peptide encoded in the mitochondrial 12S rRNA gene. Unlike nuclear-genome-encoded peptides, MOTS-c originates inside the mitochondrion itself, acting as a retrograde signal from mitochondria to nucleus. Why mitochondrial-origin matters: MOTS-c activates AMPK, upregulates PGC-1α, and enhances insulin sensitivity through pathways that parallel the cellular response to exercise. It’s been called an exercise mimetic in the metabolic-research literature. IF the research endpoint is mitochondrial function, insulin sensitivity, or exercise-pathway pharmacology, THEN MOTS-c is the mitochondrial peptide with the densest published evidence. SO it belongs in studies of metabolic aging, type-2 diabetes models, or compound exercise-mimetic signaling. Lyophilized, ≥99% purity, CoA-verified.

Specifications

CAS number: 1627580-64-6
Molecular formula: C101H152N28O22S2
Molecular weight: 2174.55 g/mol
Purity: >99% HPLC
Form: Lyophilized powder
Storage: Store at 2–8°C

For laboratory research use only. Not for human or veterinary use.